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VICODIN medications (hydrocodone bitartrate and acetaminophen tablet) comes in different strengths and amounts, which is referred to as the dose of Vicodin 500/5mg. The appearance of Vicodin can differ based on the dose. Your doctor or health care may change the dosage and prescription of Vicodin to get you the best results possible.

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Acute over dosage of Vicodin hydrocodone (bitartrate and acetaminophen) tablets can be manifested by respiratory depression, somnolence progressing to stupor or coma, cold, skeletal muscle flaccidity and clammy skin, constricted pupils and in some cases edema, bradycardia, pulmonary, partial or complete airway obstruction, hypotension, atypical snoring, and death.

Acetaminophen

Dosage dependent, potentially fatal hepatic necrosis is the most serious adverse side effect of acetaminophen over dosage. Hypoglycemic coma, renal tubular necrosis and coagulation defects may also occur.

Early symptoms following a potentially hepatotoxic overdose may include: diaphoresis, vomiting, nausea and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 72 hours post ingestion.

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Treatment Of Overdose

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In case of over dosage, priorities are the re-establishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures (including vasopressors and oxygen) in the management of circulatory shock and pulmonary edema as indicated. Arrhythmias or cardiac arrest will required advanced life support techniques.

The opiate naloxone or nalmefene and antagonist are specific antidotes to respiratory depression resulting from opiate overdose. For clinically significant respiratory or circulatory depression secondary to Vicodin (hydrocodone bitartrate and acetaminophen) tablets over dosage, administered an opioid antagonist. Opioid antagonists shouldn’t be administered in the absence of clinical significant respiratory or circulatory depression secondary to Vicodin hydrocodone bitartrate and acetaminophen tablets overdose.

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Because the duration of opioid reversal is expected to be less than the duration action of Vicodin (hydrocodone bitartrate and acetaminophen) tablets is carefully monitor the patient until spontaneous respiration is reliably reestablished. If the response to an opioid antagonist is suboptimal or only brief in nature, administered additional antagonist as directed by the product prescribing information. The usual adult dose is one or two tablets every 4 to 6 hours as needed for pain.

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