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Hydrocodone 650/10mg is an opioid pain medication sold under the brand name Zohydro ER and Hysingla ER is an used to treat severe pain. If other measures are not sufficient. It is also used as a cough for adults only. It is taken after lunch and diner with milk. Typically it is sold as the combinations acetaminophen or hydrocodone or ibuprofen or hydrocodone.

These medicines is common side effects include constipation, nausea, dizziness and sleepiness and serious side effects may include QT prolongation, low blood pressure, seizures, respiratory depression and serotonin syndrome. Decreasing the dose may be result in opioid withdrawal. Hydrocodone medicines is not recommended to use during pregnancy or breastfeeding. Hydrocodone is believed to work by activate opioid receptors, mainly in the brain and spinal cord.

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Hydrocodone medicines was discovered in 1923, while the long-acting formulation was approved for medical use in the United States of America and Canada in 2013. It is most commonly prescribed in the United States of America and Canada, which consumed 99% of the worldwide supply as of 2010. It was the 118th most commonly prescribed medication in the United States of America and Canada in 2017. It is made by opium poppy after it has been converted to codeine.

Hydrocodone is used to treat moderate to severe ongoing body pain. In liquid formulations and it is used to treat cough. In the study comparing the potency of hydrocodone medicines to that of oxycodone medicines, it was found that it took 50% more hydrocodone to achieved the same degree of miosis. Doctor’s interpreted that oxycodone medicines is about 50% more potent than hydrocodone medicines.

Some references states of the USA and Canada that the analgesic action of hydrocodone begins in 20–30 minutes and lasts about 4–8 hours. The manufacturing company information said onset of action is about 10–30 minutes and duration is about 4–6 hours.

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Signs and symptoms of hydrocodone misuse and abuse

• Blurry vision
• Lightheadedness
• Dizziness
• Itchy skin
• Constipation
• Drowsiness
• Pinpoint pupils
• Dry mouth
• Warm, flushed skin
• Slowed speech

Signs and symptoms of hydrocodone addiction

• Abandoning hobbies
• Strained relationships
• Social isolation

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